Putative biomarker of working memory systems development during childhood and adolescence.

Keage HAD Clark CR, Hermans DF, Williams LM, Kohn MR, Clarke S, Lamb C, Crewther D, Gordon E (in press). Putative biomarker of working memory systems development during childhood and adolescence, Neuroreport, , -.



The study aimed to identify brain functional indicators of working memory systems development between 6 and 18 years. Event related potentials (ERPs) were recorded from 251 normally developing children to stimuli requiring the updating of working memory. Cluster analysis of ERP componentry divided the sample into three clusters (mean ages 9, 12 and 16 years), with ascending cluster membership independently associated with improved task-performance. The clusters correspond to periods of gray matter loss and white matter increase observed in developing children, supporting the view that the clusters delineate three key qualitative stages in advancing cognitive capability during the maturation of higher brain systems function. This outcome identifies a biomarker with the potential for assessing abnormalities in the rate of brain development..